Description

What is Physiological Intracytoplasmic Sperm Injection (PICSI)? PICSI is an advanced form of the ICSI fertility procedure. Unlike standard ICSI, which selects sperm based on appearance and movement, PICSI helps choose biologically mature sperm that have better DNA quality and a higher chance of successful fertilization and healthy embryo development. At Simran IVF®, PICSI is offered to couples facing male factor infertility, repeated IVF/ICSI failures, unexplained infertility, or recurrent miscarriages. Why is PICSI Used? Some sperm may look normal but have DNA damage. PICSI selects sperm that bind to hyaluronic acid (HA)—a natural substance around the egg. These sperm are usually more mature, healthier, and less likely to cause genetic problems. How Does PICSI Work? Semen sample is collected and prepared Sperm are placed in an HA-coated dish Only mature sperm bind to HA Selected sperm are injected into the egg using ICSI This natural selection step helps improve embryo quality. Who Can Benefit from PICSI? PICSI may help couples with: Repeated IVF/ICSI failure High sperm DNA fragmentation Unexplained infertility Early pregnancy loss Older male partners Benefits of PICSI Healthier sperm selection Lower DNA damage Better embryo development Reduced miscarriage risk Improved pregnancy outcomes PICSI at Simran IVF® is recommended only when medically necessary, ensuring safe, ethical, and personalized fertility care.

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